miR-21 inhibitor 37( —— )

Catalog No. M17041 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

miR-21 inhibitor 37
Note

Research use only, not for human use.
Brief Description

miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays.
Description

miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7 uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels in A498 RCC cells, sensitizes cells to topotecan-induced apoptosis.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

MicroRNA
Recptor

MicroRNA
Research Area

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Indication

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CAS Number

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Formula Weight

415.413
Molecular Formula

C21H17N7O3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(E)-1-(3-(5-amino-4-(3-(4-(prop-2-yn-1-yloxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one oxime

1. Naro Y, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.7b01891.

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